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KMID : 0605620170240010026
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Journal of Korean Society of Biological Psychiatry
2017 Volume.24 No. 1 p.26 ~ p.31
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A Preliminary Study on the Circadian Rhythm of Autonomic Nervous System in Patients Admitted to Intensive Care Unit, Using the Heart Rate Variability
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Oh Joo-Young
Cho Dong-Rae
Kim Jong-In
Park Jae-Sub
Heo Jae-Seok
Kim Jae-Jin
Na Se-Hee
Shin Cheung-Soo
Lee Bo-Reom
Park Jin-Young
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Abstract
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Objectives : A normal circadian rhythm of autonomic nervous system function stands for the daily change of sympathetic and parasympathetic modulation, which can be measured by heart rate variability (HRV). Generally, patients in the intensive care unit (ICU) are prone to sleep-wake cycle dysregulation, therefore, it may have an influence on the circadian rhythm of autonomic nervous system. This study was designed to interpret possible dysregulation of autonomic nervous system in ICU patients by using HRV.
Methods : HRV was assessed every 3 hours in 21 ICU patients during a 7-minute period. The statistical differences of HRV features between the morning (AM 6 : 00-PM 12 : 00), and the afternoon (PM 12 : 00-PM 18 : 00) periods were evaluated in time domain and frequency domain.
Results : Patients showed significantly increased normalized power of low frequencey (nLF), absolute power of low frequencey (LF)/ absolute power of high frequencey (HF) in the afternoon period as compared to the morning period. However, normalized power of high frequency (nHF) was significantly decreased in the afternoon period. There was no statistically significant difference between the morning period and the afternoon period in the time domain analysis.
Conclusions :The increased sympathetic tone in the afternoon period supports possible dysregulation in the circadian rhythm of autonomic nervous system in ICU patients. Future studies can help to interpret the association between autonomic dysregulation and negative outcomes of ICU patients.
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KEYWORD
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Heart rate variability, Circadian rhythm, Autonomic nervous system, Intensive care unit
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